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Patients may require different levels of sedation for the same procedure and may attain varying levels of sedation during a single procedure.In general, diagnostic and uncomplicated therapeutic upper endoscopy and colonoscopy are successfully performed using moderate (conscious) sedation.Lorazepam works by acting on receptors in the brain called GABA receptors.This causes the release of a neurotransmitter called GABA in the brain.Sedation is intended primarily to reduce a patient's anxiety and discomfort, consequently improving their tolerability and satisfaction for the procedure.Endoscopic sedation also minimizes a patient's risk of physical injury during an examination and provides the endoscopist with an ideal environment for a thorough examination.

With deep sedation, patients respond only to painful stimuli, and airway support may be required.

At the level of general anesthesia, patients are unresponsive, and airway support is necessary [1-3].

The degree of sedation should be titrated to achieve patient comfort and a successful procedure.

However, not all patients require sedation for endoscopic procedures.

Some patients are quite comfortable with no sedation, or only minimal sedation, depending on the type and duration of the procedure.

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